I checked out a project that tried a similar approach, but it ran into issues with using multimethods for subscriptions, because it is hard/impossible to detect when the definitions change, so proper hot-reloading breaks. I think that is why re-frame does it like it does (e.g., reg-sub.) Did you consider or run into that problem with this approach?

I have not seen an issue with hot-reload in my playtime app I'm using this in, but I'll keep an eye out for it.