next.jdbc (latest develop branch, and latest SNAPSHOT) "supports" XTDB v2 officially -- XTDB is part of the test suite, and logic has been added to handle the primary key being _id and not having auto-generation (which the tests assume for all other databases) and differences such as INSERT .. RETURNING * not actually returning anything. You can use :dbtype "xtdb" in your db-spec (and you'll need :dbname "xtdb" as well, per recent changes in XTDB 2.0.0 Beta 4). I'll be working through the next.jdbc docs over the next few weeks adding notes about XTDB usage, and looking at the changes needed in the tests to see if there are improvements worth discussing with the XTDB team in the New Year.