Using reagent/create-class and reagent-render you can probably do something like

(defn highcharts
   [& {:keys [my kw args}]
   (let [js-highcharts (atom nil)]
      (r/create-class
        {:display-name "highcharts"
         :reagent-render
           (fn [& {:keys [my kw args]}]
               [:> hightcharts-react
                   {:ref (fn [instance]
                           (when instance
                               (reset! js-hightcharts instance)) ....