I’ve never tried Smalltalk. I’m curious about how you think it compares when it comes to interactive programming.

In smalltalk environments, you define the classes and methods interactively. So it is more dynamic. You are constructing a database of code,not a set of files.

That is actually very similar to Clojure. You store the code in files, but you don’t need to create them that way. In fact I often have defined a completely different program than what I have in my files.