Has anyone used component with re-frame? I’m trying to figure out how to access a Datascript DB in re-frame’s handlers.

I would not expect much success there. Re-frame initializes and holds state in one if its namespaces. Everything uses that state atom directly by name, the same way mount works. This is also why it is difficult to use with devcards.

Maybe you should look at https://github.com/mpdairy/posh and/or https://github.com/metasoarous/datsys