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If you've ever struggled with AOT and packaging misery (NoClassDefFoundException, etc.) while getting Clojure lambdas to work (via any of the libraries like lambada, etc.) you don't need any of that! Instead:

(ns the.namespace)
(deftype Lambda []
  :load-ns true
  (handleRequest [this in out context]
     YOUR CODE))
Uberjar it up and then point AWS to "the.namespace.Lambda" as the entry class. (The load-ns bit means load the containing namespace when this deftype's class gets loaded by AWS)